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Grade 5 treatment-related adverse events occurred in two patients (0.8%) in the combination arm (sepsis, febrile neutropenia) and one patient (0.4%) in the control arm (sepsis). Grade 3 or 4 treatment-related adverse events were seen in 25.6% vs 5.8% of patients, respectively. In the atezolizumab alone arm, it was 2.1 months.
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The 12-month OS rates were 56.3% and 44.1%, respectively.A total of 197 patients in the lurbinectedin-atezolizumab arm discontinued maintenance, as did 208 patients in the atezolizumab-alone arm. The proportion of patients who responded to induction was 87.3% in the lurbinectedin-atezolizumab arm and 88.8% in the atezolizumab-alone arm. Adding lurbinectedin to atezolizumab as first-line maintenance improved progression-free survival (PFS) and overall survival (OS) in patients with extensive-stage small cell lung cancer (ES-SCLC) in the phase 3 IMforte trial.1,2
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That number always shocks me, because when I give atezolizumab maintenance alone, I know that after 2 or 3 cycles, in our first scan, we see progressive disease. What were the safety outcomes with the addition of lurbinectedin? Whereas if you got atezolizumab, did you go on to get other therapies…?
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In the lurbinectedin and atezolizumab arm, 6.2% of patients stopped treatment due to side effects compared to 3.3% in the atezolizumab alone arm. Treatment-related adverse events occurred in 83.5% of patients in the lurbinectedin and atezolizumab arm, compared to 40% in the atezolizumab alone arm. They were randomly assigned to receive either lurbinectedin and atezolizumab (242 patients) or atezolizumab alone (241 patients). The integration of lurbinectedin—a novel DNA-damaging agent—into the maintenance setting alongside atezolizumab following initial chemo-immunotherapy represents an important next step.
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